| Methods |
RCT |
| Participants |
40 children, age range 2 to 12 years (median 7.5 years), paediatric clinic, Italy, acute febrile bronchitis |
| Interventions |
Mucolytic: letosteine 25 mg 3 times daily for 10 days |
| Outcomes |
Cough score from 0 to 3, unclear how this was measured |
| Notes |
No adverse effects reported in either group |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Not reported |
| Allocation concealment (selection bias) |
Unclear risk |
Not reported |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Blinding reported |
| Incomplete outcome data (attrition bias)
All outcomes |
Unclear risk |
Not reported |
| Selective reporting (reporting bias) |
Unclear risk |
Not reported |
| Other bias |
Unclear risk |
Interim power calculation carried out during study by independent external statistician |
