| Methods |
RCT |
| Participants |
99 factory workers in the chemical industry, age range 15 to 44 years, Germany, URTI |
| Interventions |
Mucolytic: Bisolvon linctus (N‐cyclohexyl‐N‐methyl‐(2‐amino‐3,5‐dibrombenzyl) ammonium chloride 4 mg in 5 ml 3 times daily for an average of 4 days |
| Outcomes |
Outcome measurement not clearly described; used 4‐point scale. Frequent cough (defined as cough every 2 to 4 minutes) |
| Notes |
Study did not report on adverse effects |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Not reported |
| Allocation concealment (selection bias) |
Unclear risk |
Not reported |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Patients and providers blinded; outcome assessor blinding not reported |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
93% follow‐up; difference between groups not reported |
| Selective reporting (reporting bias) |
Unclear risk |
Not reported |
| Other bias |
Unclear risk |
No power calculation reported |
