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. 2020 Feb 15;12(2):343–360.

Figure 8.

Figure 8

The impact of Icariin on Smad and MAPK signaling pathways in HDM-exposed mice. A. Western blot was used to detect the phosphorylation of Smad-2 and Smad-3 and total level of Smad-2/3 and Smad-4 proteins of Smad signaling pathway. B. The phosphorylation of Erk, Jnk and p38 and total level of Erk, Jnk and p38 proteins of MAPK signaling pathway were detected by western blot. C. The expressions of Smad-2, Smad-3 and Smad-4 mRNA were determined by quantitative real-time PCR. D. The expressions of Erk, Jnk and p38 mRNA were determined by quantitative real-time PCR. #P<0.05, ##P<0.01 versus control group, *P<0.05, **P<0.01 versus HDM group.