Figure 3.

1,25(OH)₂D insufficiency increases the augmented, age-related, osteoclastic bone resorption. A. Representative micrographs of sections of the first lumbar vertebral from 3-, 9- and 18-month-old Cyp27b1 ^+/- mice and wild-type (WT) mice stained histochemically for TRAP, a specific osteoclastic marker. B. The surface of osteoclasts relative to bone surface (Oc.S/B.S). Values are means ± SEM of 6 determinations per group. ***P<0.001, compared with age-matched WT mice. ##P<0.01, #P<0.05, compared with genotype-matched 3-month-old mice. &&P<0.01, &P<0.05, Compared with genotype-matched 9-month-old mice.