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. 2020 Mar 8;8(1):e000148. doi: 10.1136/jitc-2019-000148

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Comparison of the expansion capacity and transduction efficacy of CAR-T cells from ALL (n=38) and NHL (n=53) patients. (A) Total viable cell numbers (x10e6) ± SE. On day 2 only part of the cells were transduced and further expanded. (B) Fold expansion ± SE in comparison to the number of cells taken for transduction on day 2. (C) Fold expansion of total viable cells according to age. (D) Transduction efficacy displayed as percent of CD3+F(ab)₂+ CAR-T cells on day 6 and day 9. *p≤0.01; **p≤0.001. ALL, acute lymphoblastic leukemia;CAR-T, chimeric antigen receptor T cells; NHL, non-Hodgkin's lymphoma.