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. 2020 Mar 8;8(1):e000148. doi: 10.1136/jitc-2019-000148

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Phenotype analysis of CAR-T infusion products derived from ALL (n=12) and NHL (n=12) patients. Cells were gated on CD3+ F(ab)₂+ CAR-T cells. (A) Differentiation status. TN (naïve T cells), CD3+CD45RA+CCR7+; TCM (central memory T cells), CD3+CD45RA−CCR7+; TEM (effector memory T cells), CD3+CD45RA−CCR7−; TEMRA (effector T cells), CD3+CD45RA+CCR7−. (B) Chemokine receptor profile. *p<0.01. SD are presented. ALL, acute lymphoblastic leukemia; CAR-T, chimeric antigen receptor T cells; NHL, non-Hodgkin's lymphoma.