Table 4.

Comparison of CAR-T and TIL infusion products

	CAR-T n=24	TIL (n=40–88)	P value
T cell subpopulations
CD8+	58±16	63±24 (n=88)	0.386
CD4+	42±17	35±24 (n=88)	0.200
Differentiation status
TN	49±18	0.05±0.10 (n=88)	≤0.001
TCM	17±14	2.3±2.5 (n=88)	≤0.001
TEM	18±13	96.8±3.0 (n=88)	≤0.001
TEMRA	15±13	0.82±1.5 (n=88)	≤0.001
Co-stimulatory / co-inhibitory molecules
CD28 + CD3+	47±26	52±20 (n=88)	0.396
PD1 + CD3+	26±8	26±15 (n=40)	0.494
LAG3 + CD3+	25±11	10±4 (n=40)	≤0.001
TIM3 + CD3+	50±15	61±14 (n=40)	0.004
Chemokine receptors
CCR5 + CD3+	12±13	80±24 (n=56)	≤0.001
CCR4 + CD3+	33±14	27±12 (n=88)	0.032
CXCR3 + CD3+	79±12	86±20 (n=88)	0.076

Phenotype analysis of 24 CAR-T cells and 40 to 88 TIL infusion products. Cells were gated on viable cells. TIL, tumor infiltrating lymphocytes, TN (naïve T cells), CD3+CD45RA+CCR7+; TCM (central memory T cells), CD3+CD45RA−CCR7+; TEM (effector memory T cells), CD3+CD45RA−CCR7−; TEMRA (effector T cells), CD3+CD45RA+CCR7−.

CAR-T, chimeric antigen receptor T cells.