Figure 1.

Treatment and PK sampling schedule. Following malaria diagnosis on study day 0, six doses of AL were administered from study days 0 to 3 (green box). Plasma PK samples were collected on day 0 prior to treatment, before (0hr) and at 0.5, 1, 2, 3, 4, 8, 24, 120 (day 8*), 264 (day 14), and 432 (day 21) hr post sixth dose (blue arrows). Active follow up for malaria was performed on days 28 and 42 (pink arrows). The 120 hr sample occurred on day 8 in this study due to the elongated dosing schedule. Previously studies using the standard three day dosing report the 120 hr sampling point as day 7 values. Given that sampling occurred at the same post-dose time we will refer to day 8 as day 7 throughout. AR, artemether; DHA, dihydroartemisinin; LR, lumefantrine.