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Comparison of bulk RNA-seq versus single-cell RNA-seq. Heterogeneity in expression profiles across cell types is masked by bulk sequencing methods. Transposable element (TE) expression may vary across cell types, between cells of the same type, and within the same cells across time. Single-cell methods are necessary to reveal this heterogeneity, but software for single-cell data analysis is not currently optimized for handling TEs.
