TABLE 2.
Tissue and subcellular distribution of monocarboxylate transporters
| Transporter | Unigene Name | Tissue Distribution | Subcellular Localization | Expression | Species | References |
|---|---|---|---|---|---|---|
| MCT1 | SLC16A1 | Ubiquitous | Apical and basolateral membrane | Human | Halestrap and Meredith, 2004; Gill et al., 2005 | |
| MCT2 | SLC16A7 | Liver | Basolateral membrane | Protein | Human | Garcia et al., 1994; Lin et al., 1998; Halestrap and Meredith, 2004; Wilson et al., 2005; Becker et al., 2010b |
| Kidney | Basolateral membrane | Protein | Human | |||
| Apical | Mouse | |||||
| Skeletal muscle | Protein | Human | ||||
| Heart | Protein | Human | ||||
| Brain | Protein | Human | ||||
| Spleen | Protein | Human | ||||
| Testis | Basolateral membrane | Protein | Human | |||
| Pancreas | Protein | Human | ||||
| MCT3 | SLC16A8 | Retinal pigment epithelium | Basolateral membrane | Halestrap and Meredith, 2004 | ||
| MCT4 | SLC16A3 | Kidney | Basolateral membrane | Protein | Human | Dimmer et al., 2000; Halestrap and Meredith, 2004; Settle et al., 2004; Gill et al., 2005; Wang et al., 2006b |
| Skeletal muscle | Protein | Human | ||||
| Intestine | Basolateral membrane | Protein | Human | |||
| Heart | Protein | Human | ||||
| Lung | Protein | Human | ||||
| MCT5 | SLC16A4 | Liver | mRNA | Rat | Felmlee | |
| Kidney | mRNA | Rat | ||||
| MCT6 | SLC16A5 | Kidney | mRNA | Rat | Felmee | |
| Intestine | Basolateral membrane | Protein | Human | Gill et al., 2005 | ||
| MCT7 | SLC16A6 | Kidney | mRNA | Rat | Felmlee | |
| MCT8 | SLC16A2 | Liver | Sinusoidal membrane | mRNA | Human, Rat | Bonen et al., 2006; Nishimura and Naito, 2008; Roberts et al., 2008 |
| Kidney | Basolateral membrane (proximal tubule) | mRNA | Human, Rat | Felmlee | ||
| Adrenal gland | mRNA | Human | ||||
| Brain (neurons, blood brain barrier) | mRNA | Human | ||||
| Choroid plexus | Apical membrane | Protein | Human | |||
| Mouse | ||||||
| Ovary | mRNA | Human | ||||
| Thyroid gland | mRNA | Human | ||||
| Uterus | mRNA | Human | ||||
| Placenta | mRNA | Human | ||||
| Heart | mRNA | Human | ||||
| Protein | Rat | |||||
| Lung | mRNA | Rat | ||||
| MCT10 | SLC16A10 | Liver | mRNA | Rat | Felmlee | |
| Kidney | mRNA | Rat | ||||
| Intestine | mRNA | Rat | ||||
| Lung | mRNA | Rat | ||||
| MCT11 | SLC16A11 | Liver | mRNA | Rat | Felmlee | |
| Kidney | mRNA | Rat | ||||
| Lung | mRNA | Rat | ||||
| MCT12 | SLC16A12 | Liver | mRNA | Rat | Felmlee | |
| Kidney | mRNA | Rat | ||||
| Lung | mRNA | Rat | ||||
| MCT13 | SLC16A13 | Liver | mRNA | Rat | Felmlee | |
| Kidney | mRNA | Rat | ||||
| Intestine | mRNA | Rat | ||||
| Lung | mRNA | Rat | ||||
| MCT14 | SLC16A14 | Peripheral blood mononuclear cells | mRNA | Human | Banerjee et al., 2017 | |
| Kidney | mRNA | Rat | Felmlee |