Table 4.
Relation between miRNA-224 relative expression and the different laboratory and clinical parameters
| Parameter | r (p-value) | Parameter | Mean ±SD of miRNA-224 | p-value |
|---|---|---|---|---|
| ALT | 0.342 (0.003)* | Child class | 0.003* | |
| AST | 0.278 (0.018)* | B | 12.48 ±31.80 | |
| Albumin | –0.353 (0.002)* | C | 47.64 ±71.34 | |
| T-Bil | 0.123 (0.304) | BCLC stage | 0.013* | |
| ALP | 0.357 (0.002)* | Very early | 20.17 ±23.15 | |
| GGT | 0.062 (0.605) | Early | 5.69 ±6.73 | |
| BUN | 0.538 (0.00)* | Intermediate | 137.19 ±0.00 | |
| Creatinine | 0.256 (0.03)* | Advanced | 87.47 ±78.43 | |
| INR | 0.308 (0.008)* | Number of FLs | 0.003* | |
| Hb | –0.183 (0.123)* | Single | 100.88 ±63.79 | |
| WBCs | –0.083 (0.490)* | Two/three | 21.09 ±51.22 | |
| Platelets | –0.357 (0.002)* | More than three |
62.14 ±83.93 | |
| AFP involved |
0.26 (0.027)* | Liver lobes | 0.003* | |
| One lobe | 118.21 ±62.04 | |||
| Size of largest FL | –0.003 (0.987) | Both lobes | 42.66 ±66.78 | |
| PV thrombosis | 0.825 | |||
| Positive | 69.65 ±68.38 | |||
| Negative | 62.22 ±77.36 | |||
| LN metastasis | 0.001* | |||
| Positive | 18.77 ±16.10 | |||
| Negative | 76.78 ±77.60 | |||
| Extrahepatic spread |
0.013* | |||
| Positive | 137.19 ±0.00 | |||
| Negative | 61.54 ±73.01 |
ALT – alanine aminotransferase, AST – aspartate aminotransferase, T-Bil – total bilirubin, ALP – alkaline phosphatase, GGT – g-glutamyl-transpeptidase, BUN – blood urea nitrogen, PT – prothrombin time, INR – international normalized ratio, Hb – hemoglobin, WBCs – white blood cells, AFP – α-fetoprotein, miRNA-224 – micro-ribonucleic acid 224, FL – focal lesion, BCLC – Barcelona Clinic Liver Cancer, n – number, PV – portal vein, LN – lymph node, r – Pearson correlation coefficient
*
statistically significant at p < 0.05