Table 5.
Diagnostic performance of miRNA-224 relative expression and α-fetoprotein in predicting hepatocellular carcinoma (HCC) in liver cirrhosis patients
| Cut off | AUC | Sensitivity | Specificity | Accuracy | Asymptotic Sig. | Asymptotic 95% confidence interval | ||
|---|---|---|---|---|---|---|---|---|
| Lower bound | Upper bound | |||||||
| miRNA-224 | 2.00 | 0.844 | 86.0 | 81.0 | 83.0 | 0.001* | 0.710 | 0.977 |
| AFP (ng/ml) | 20.0 | 0.965 | 94.0 | 90.0 | 92.0 | 0.0001* | 0.930 | 0.99 |
| Combined miRNA-224 and AFP | 0.939 | 95.0 | 92.1 | 93.2 | 0.0001* | 0.885 | 0.994 | |
AFP – α-fetoprotein, miRNA-224 – micro-ribonucleic acid 224, AUC – area under the curve