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Self-association properties of insulin analogs
| Analog | Hexamer lifetimes (t½) | Calculated SEC massa |
|---|---|---|
| min ± S.D. | kDa | |
| WT insulin | 8.2 ± 1.3 | 6.8 |
| Insulin lispro | 4.6 ± 0.3 | 4.2 |
| OrnB29 | 8.2 ± 0.8 | 6.6 |
| SerB24 OrnB29 | 2.3 ± 0.2 | 4.9 |
| GlyB24 OrnB29 | 1.2 ± 0.2 | 4.9 |
a Proteins were made 0.6 mm in a zinc-free buffer and applied to the SEC column as described under “Experimental procedures”; masses were calculated from Fig. S9.
