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Single-dose administration of CHO-sKlotho is protective against IRI in rats. A, pharmacokinetic profiles of HEK- and CHO-sKlotho; B, IRI, serum creatinine; C, IRI, BUN; D, IRI, GFR; E, IRI, albuminuria; F, IRI, renal cortical α-smooth muscle cell actin (scale bar, 200 μm). Data are shown as mean ± S.E. *, p < 0.05 versus vehicle, ANOVA.
