Table 1.
Key pharmacokinetic parameters of CHO-sKlotho in rats following a single IV or IP administration at 0.5 mg/kg
Values presented are mean ± S.D. with n = 3. NA, not applicable; CL, systemic clearance; Vc, central volume of distribution; Vss, volume of distribution at steady state; t1/2, terminal half-life; Tmax, time to Cmax; Cmax, observed maximal concentration; AUC(0-∞), area under the concentration-time curve at steady state; F, bioavailability.
| Route | Gender/n | CL | Vc | Vss | t½ | Tmax | Cmax | AUC(0-∞) | F |
|---|---|---|---|---|---|---|---|---|---|
| ml/h/kg | ml/kg | ml/kg | h | h | ng/ml | ng·h/ml | % | ||
| IV | Male/3 | 15.8 ± 1.7 | 47.4 ± 10.7 | 120 ± 15.6 | 12.2 ± 0.9 | 0.083 | 9327 ± 1698 | 31923 ± 3233 | NA |
| IP | Male/3 | NA | NA | NA | 13.0 ± 1.7 | 2 | 1117 ± 473 | 15162 ± 4835 | 47.5 |