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. 2019 Dec 30;295(10):2948–2958. doi: 10.1074/jbc.RA119.010365

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© 2020 Newman et al.

Author's Choice—Final version open access under the terms of the Creative Commons CC-BY license.

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Figure 3. — Comparison of the mode of recognition of the FHK and FHL consensus sequences. A, comparison of the recognition helix of the FHL-bound FOXN1 (shown in gray) with the FHK-specific FOXK1 (shown in cyan). B, comparison of the DNA conformations of the FHL site bound to FOXN1 (black) and the FKH site bound to FOXO3 (red), DNA molecules are superposed based on the structural alignment of the FOXN1 and FOXO3 proteins, with the respective motifs highlighted. C, comparison of the major and minor groove widths for FOXN1 and FOXO3 with values for ideal B-form DNA shown for reference. D, space-filling representation of the DNA bound to FOXN1 (upper panel) and FOXO3 (lower panel). The more prominent bending and greater distance to the recognition helix can be seen in the FOXO3 DNA complex structure.