FIG 12.

Virus realms, Baltimore classes, and the global network of the virus world. Gray shapes denote the four virus realms, and white rectangles denote the seven Baltimore classes. The colored circles contain ribbon diagram representations of the structures of hallmark virus proteins and the RNA recognition motif (RRM) domain. Circles are connected to groups of viruses, in which a given viral hallmark protein or domain is represented, and to BCs by lines of the corresponding color. Abbreviations: DJR, double jelly roll; PolB, family B DNA-directed DNA polymerase; RCRE, rolling-circle replication (initiation) endonuclease; RdRp, RNA-directed RNA polymerase; RT, reverse transcriptase; S3H, superfamily 3 helicase; SJR, single jelly roll.