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. 2020 Jan 29;31(3):501–516. doi: 10.1681/ASN.2019050523

Figure 5.

Figure 5.

The endothelial PHD2/HIF-1 axis suppresses the expression of EC-adhesion molecules and proinflammatory cytokines. (A) Transcript levels of Icam1 and Vcam1 in injured kidneys from EC-Phd2HIf1, EC-Phd2Hif2 mutant mice and their corresponding Cre− littermate controls at day 3 after unilateral renal IRI (n=7–9 for EC-Phd2Hif1 versus Cre-, Icam1 P=0.06, Vcam1 P=0.19; n=8 for EC-Phd2Hif2 versus Cre-, Icam1 P=0.002, Vcam1 P=0.08; one-way ANOVA with Sidak correction for multiple comparisons). (B) Relative (Rel.) Cxcl1, Cxcl2, and Tnfa levels in IR and CTL kidneys of mice with the indicated genotypes at day 3 after unilateral renal IRI (n=7–9 for EC-Phd2Hif1 versus Cre-, Cxcl1 P=0.03, Cxcl2 P=0.042, Tnfa P=0.09; n=8 for EC-Phd2Hif2 versus Cre-, Cxcl1 P=0.0008, Cxcl2 P=0.008, Tnfa P=0.002; one-way ANOVA with Sidak correction for multiple comparisons). Error bars represent SEM. *P<0.05, **P<0.01, ***P<0.001. CTL, contralateral kidney; IR, kidney subjected to unilateral IRI.