Figure 4.

Comparison of murine and human proteomic data sets identified conserved and individual features of podocyte damage. (A and B) Comparison of a wild-type mouse podocyte proteome with the Doxorubicin and the LPS datasets reveals that a majority of the detected proteins are podocyte specific and some of them are decreased upon injury. (C) Comparison of homologous protein expression in Doxorubicin- and LPS-treated FACS-sorted native podocytes with single human glomerular FSGS samples revealed only minor similarities. (D) Individual plotting and statistical outlier testing (FDR<0.01) revealed two interesting candidates, Filamin-B and ATP1B1. Both are significantly upregulated in the Doxorubicin model and the human FSGS sample. (E) Plotting of the LPS samples versus the human FSGS samples did not reveal increased statistical outliers in either condition.