Skip to main content
. 2020 Mar 9;15(3):e0229769. doi: 10.1371/journal.pone.0229769

Fig 5. MK-4 administration attenuated neuronal loss in the hippocampal subregions induced by I/R injury.

Fig 5

Using Nissl staining neuronal density was quantified in different hippocampal subregions. 7 days after reperfusion neuronal density was diminished in (A) CA1, (B) CA3 and (C) DG hippocampal subregions. But MK-4 injection could prevent neuronal loss induced by I/R injury. (Scale bar = 20 μm in representative examples of Nissl staining). Data are presented as mean±SEM. * p < 0.05, ** p < 0.01 and *** p < 0.001 compared to control, + p < 0.05, ++ p < 0.01 and +++ p < 0.001 compared to I/R+MK4 group (n = 6).