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. 2020 Mar 9;15(3):e0229769. doi: 10.1371/journal.pone.0229769

Fig 8. Reduced astrogliosis and EAAT2 (glutamate transporter 1, GLT-1) induction following MK-4 administration in I/R rat model.

Fig 8

The mRNA expression level of GFAP and GLT-1 genes was quantified using real-time PCR relative to GAPDH reference gene in rat’s hippocampus. (A) I/R injury induced astrogliosis by elevated GFAP expression level, but MK-4 injection inhibited it. (B) GLT-1 mRNA level was reduced following I/R injury and MK-4 administration backed it to the control level. Data are presented as mean±SEM. * p < 0.05 and ** p < 0.01 compared to control, + p < 0.05 compared to I/R+MK4 group (n = 6).