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. 2020 Mar 9;15(3):e0229135. doi: 10.1371/journal.pone.0229135

Table 4. Univariate and multivariate logistic regression models of lactate index for in-hospital mortality.

Lactate Index Univariate Logistic Regression Model Multivariate Logistic Regression Model
OR (95% CI) Z value p value OR (95% CI) Z value p value
Max lactate at T0 (mmol/L) 1.200 (1.142–1.260) 7.25 <0.001 1.422 (1.065–1.898) 2.39 <0.05
Max lactate at T0 ≥3.0 (mmol/L) 1.404 (0.974–2.026) 1.82 0.069 0.627 (0.345–1.138) -1.53 0.125
Max lactate at T0 ≥ 4.0 (mmol/L) 2.251 (1.643–3.083) 5.05 <0.001 1.620 (0.845–3.109) 1.45 0.147
Max lactate at T0 ≥ 5.0 (mmol/L) 2.239 (1.725–3.173) 5.46 <0.001 0.611 (0.290–1.287) -1.30 0.195
Max lactate at T0 ≥ 6.0 (mmol/L) 2.906 (2.113–3.998) 6.56 <0.001 1.431 (0.656–3.121) 0.90 0.368
Max lactate at T12 (mmol/L) 1.264 (1.196–1.336) 8.30 <0.001 0.871 (0.660–1.149) -0.98 0.329
Max lactate at T24 (mmol/L) 1.503 (1.399–1.627) 10.08 <0.001 1.399 (1.102–1.776) 2.76 <0.01
Max lactate 0-12h (mmol/L) 1.203 (1.149–1.259) 7.97 <0.001 1.322 (0.895–1.954) 1.40 0.161
Max lactate 0-24h (mmol/L) 1.226 (1.173–1.283) 8.92 <0.001 0.664 (0.465–0.948) -2.25 <0.05
Lactate SL 0-12h (mmol/L/12hrs) 1.084 (1.028–1.144) 2.96 <0.01 0.977 (0.796–1.199) -0.23 0.821
Lactate SL 0-24h (mmol/L/24hrs) 1.115 (1.062–1.171) 4.38 <0.001 1.040 (0.929–1.165) 0.68 0.497
Δ Lac 0-12h (%) 0.994 (0.991–0.997) -4.22 <0.001 0.994 (0.984–1.004) -1.20 0.230
Δ Lac 0-24h (%) 0.987 (0.983–0.990) -7.77 <0.001 0.990 (0.978–1.001) -1.74 0.082
Δ Lac 12-24h (%) 0.989 (0.985–0.993) -5.82 <0.001 1.001 (0.993–1.008) 0.14 0.889
Δ Lac 0-12h (≥30%) 0.577 (0.427–0.781) -3.56 <0.001 1.556 (0.764–3.169) 1.22 0.223
Δ Lac 0-12h (≥20%) 0.509 (0.376–0.690) -4.36 <0.001 0.464 (0.205–1.053) -1.84 0.066
Δ Lac 0-12h (≥10%) 0.628 (0.458–0.861) -2.89 <0.01 2.349 (1.138–4.850) 2.31 <0.05
Δ Lac 0-24h (≥30%) 0.280 (0.204–0.383) -7.95 <0.001 0.924 (0.399–2.136) -0.19 0.852
Δ Lac 0-24h (≥20%) 0.236 (0.170–0.327) -8.67 <0.001 0.674 (0.250–1.818) -0.78 0.435
Δ Lac 0-24h (≥10%) 0.240 (0.170–0.340) -8.06 <0.001 1.170 (0.502–2.729) 0.36 0.716
Δ Lac 12-24h (≥30%) 0.425 (0.306–0.590) -5.11 <0.001 0.959 (0.521–1.765) -0.13 0.893
Δ Lac 12-24h (≥20%) 0.442 (0.326–0.599) -5.25 <0.001 1.282 (0.619–2.653) 0.67 0.504
Δ Lac 12-24h (≥10%) 0.379 (0.278–0.515) -6.18 <0.001 0.863 (0.438–1.701) -0.43 0.671

Hosmer-Lemeshow goodness-of-fit test (p value = 0.529).