Table IV.
Results of qRT-PCR: 32 genes with differential expression between Ripe versus Unripe Cervix in patients at term not in labor
| Symbol | Gene Name | Fold Change | P value |
|---|---|---|---|
| MYOCD | myocardin | 3.6 | *0.002 |
| VCAN | versican | 3.4 | *0.012 |
| THBS1 | thrombospondin 1 | 2.1 | *0.006 |
| FN1 | fibronectin 1 | 1.9 | *0.031 |
| COL4A2 | collagen, type IV, alpha 2 | 1.9 | *0.013 |
| COL6A2 | collagen, type VI, alpha 2 | 1.7 | *0.013 |
| LAMC1 | laminin, gamma 1 | 1.7 | *0.018 |
| LAMA2 | laminin, alpha 2 | 1.7 | *0.013 |
| COL5A1 | collagen, type V, alpha 1 | 1.6 | *0.037 |
| CTNND2 | catenin, delta 2 | 5.5 | 0.008 |
| MMP3 | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 5.3 | 0.042 |
| SELE | selectin | 3.1 | 0.036 |
| ADAMTS8 | ADAM metallopeptidase with thrombospondin type 1 motif, 8 | 2.9 | 0.010 |
| CTGF | connective tissue growth factor | 2.8 | 0.032 |
| COL8A1 | collagen, type VIII | 2.6 | 0.020 |
| VCAM1 | vascular cell adhesion molecule 1 | 2.5 | 0.017 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 2.3 | 0.012 |
| SELP | selectin P (granule membrane protein 140kDa, antigen CD62) | 2.1 | 0.017 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 2.0 | 0.017 |
| VTN | vitronectin | 2.0 | 0.039 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 2.0 | 0.004 |
| COL15A1 | collagen, type XV, alpha 1 | 2.0 | 0.015 |
| SGCE | sarcoglycan, epsilon | 1.9 | 0.025 |
| COL6A1 | collagen, type VI, alpha 1 | 1.7 | 0.043 |
| KAL1 | Kallmann syndrome 1 sequence | 1.7 | 0.012 |
| LAMB1 | laminin, beta 1 | 1.6 | 0.012 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 1.6 | 0.008 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide) | 1.6 | 0.033 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 10 | 1.6 | 0.042 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | -1.5 | 0.002 |
| TGFB1 | transforming growth factor, beta 1 | 1.5 | 0.048 |
| TIMP2 | tissue inhibitor of metalloproteinase 2 | 1.5 | 0.025 |
All genes in this table, except for CDH1, show higher expression levels in Ripe cervix compared to Unripe cervix.
*
significant by microarray and PCR analysis; fold change ≥ 1.5 and p < 0.05
Direction of fold change denotes change in ripe cervix