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. 2020 Feb 21;9:e54170. doi: 10.7554/eLife.54170

Figure 4. DREADD-mediated inhibition of Pitx2+ interneurons decreases motoneuron firing rates during fictive locomotion.

Figure 4.

(a) Schematic depicting the intact spinal cord preparation used for patch clamp recordings of lumbar motoneurons (green) during fictive locomotion. (b) Spontaneous firing recorded from a motoneuron during pharmacologically induced fictive locomotion in control conditions and after the addition of CNO; along with firing frequency data pooled for all recordings (n = 4); *p<0.05.

Figure 4—source data 1. Motoneuron firing frequency, input resistance and changes in holding current by CNO during fictive locomotion in Pitx2::Cre;hM4Di mice.