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. 2020 Jan 22;152(2):e201912450. doi: 10.1085/jgp.201912450

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© 2020 Tylock et al.

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Figure 2. — ECG analyses in anesthetized WT and LC15 mice. (A) Representative signal-averaged ECG traces aligned to the start of the Q-wave from 3-mo-old WT (n = 11 mice; black) and LC15 (n = 14 mice; red) littermate mice. The traces reflect the average of 3 s of continuous ECG recording from each mouse with beat-to-beat overlay aligned to S-wave anti-peaks. (B) Average ECG parameters calculated from the signal-averaged traces obtained from anesthetized WT (closed circles) and LC15 (open circles) mice. A subset of these mice was reanalyzed at 12 mo old (WT, n = 5 mice; LC15, n = 7 mice). (C) Representative 2-D guided M-mode echocardiography performed in 12-mo-old WT (top) and LC15 (bottom) mice. (D) Calculated average echocardiography parameters, including ejection fraction, fractional shortening, and LV mass, from WT and LC15 mice. (E) LV mass normalized to body weight. Error bars represent SEM. *, P < 0.05.