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. 2020 Jan 22;152(2):e201912450. doi: 10.1085/jgp.201912450

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© 2020 Tylock et al.

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Figure 8. — Peak outward potassium current density is reduced in ventricular myocytes from LC15 mice. (A) Representative outward potassium currents measured during 4.5-s voltage steps from a holding potential of −70 mV in myocytes from WT (left; black) and LC15 (right; red) mice. Voltage steps from −40 mV to +50 mV were sequentially increased in 10-mV increments and delivered at 10-s intersweep intervals. Insets: Currents during the initial 125 ms of depolarization on an expanded scale. (B) Average voltage dependence of peak (circles) and steady-state (diamonds) potassium current density in myocytes from WT (n = 24; closed symbols) and LC15 (n = 25; open symbols) mice. Steady-state currents were measured during the final 200 ms of each voltage step. (C) Representative potassium current decay during depolarization to +40 mV in myocytes from WT (black) and LC15 (red) mice fitted according to a second order exponential equation (blue solid curves). Error bars represent SEM. *, P < 0.05.