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. 2020 Jan 14;152(2):e201912501. doi: 10.1085/jgp.201912501

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© 2019 Queralt-Martín et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 1. — hVDAC3 forms high-conducting channels with a stable open state and voltage-induced closures. (A and B) Representative single-channel current traces obtained with reconstituted hVDAC3 (A) and mVDAC1 (B) at different applied voltages. Here, and elsewhere, dashed lines indicate zero current level and dotted lines, open and closed states of VDAC. Current records were digitally filtered at 500 Hz using a low-pass Bessel (8-pole) filter. Planar membranes were made of DOPC/DOPE/2DOPG. Membrane-bathing solutions consisted of 1 M KCl buffered with 5 mM HEPES at pH 7.4.