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. 2019 Dec 19;152(2):e201912434. doi: 10.1085/jgp.201912434

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© 2019 Gade et al.

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Figure 1. — Putative interaction site between CTD and III-IV linker. (A) Schematic of a VGSC displaying the location of the amino acids involved in the putative interaction site (numbering per Na_V1.5). VSD refers to voltage sensor domain. (B) Structure of Na_VPas (PDB accession no. 5X0M) as seen from the membrane. The putative interaction site is displayed in the zoomed-in images. (C) Sequence homology among different subtypes of human VGSCs and Na_VPas surrounding the amino acids involved in the putative interaction, which are marked in red.