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. 2019 Dec 19;152(2):e201912434. doi: 10.1085/jgp.201912434

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© 2019 Gade et al.

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Figure 2. — FGF12B and FGF13B, but not CaM, are effective in rescuing persistent current in the Δ1885 mutant Na_V1.5 channels. (A) Structure of the Na_V1.5 CTD overlaid on Na_VPas, with a zoomed-in view of the CTD (sky blue) along with CaM (red) and FGF13 (beige). The truncated protein in the Δ1885 mutant is shown in black. Below is the structure of the Na_V1.5 CTD (blue), displaying the truncated portion in black, and the critical site for FHF binding in red (H1849), and the structure of FHF displaying the amino acid (R57) critical for the interaction with VGSC CTDs, shown in red. (B) Exemplar traces displaying the persistent currents in WT and mutant Na_V1.5 channels. (C) Quantified data from WT and mutant Na_V1.5 channels. *, P < 0.05. CTL refers to "control," i.e., no additional protein expressed.