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. 2019 Dec 19;152(2):e201912434. doi: 10.1085/jgp.201912434

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© 2019 Gade et al.

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Figure 7. — Models demonstrating a potential mechanism involved in the CaM and FHF modulation of the persistent current mediated through the putative interaction between III-IV linker and CTD. Structures of the CTD complexes containing FHF/CaM or CaM only overlaid on Na_VPas show FHF (A) and CaM (B) positioned on CTD to stabilize the interaction between III-IV linker and CTD. (A) Structure of Na_VPas (PDB accession no. 5X0M) overlaid with the Na_V1.5 CTD in complex with FGF13 (PDB accession no. 4DCK). (B) Structure of Na_VPas overlaid with the Na_V1.5 CTD in complex with CaM (PDB accession no. 4OVN).