Table S1. Summary of activation properties.
| NaV1.5 (Control or CaM overexpressed) | V1/2 activation | k | n |
|---|---|---|---|
| WT | -45.7 ± 0.5 | 4.1 ± 0.1 | 20 |
| K1493I | -48.2 ± 0.8 | 3.0 ± 0.3 | 5 |
| K1493A | -46.0 ± 0.8 | 3.8 ± 0.4 | 7 |
| K1493E | -44.7 ± 1.1 | 5.1 ± 0.3 | 26 |
| K1492 | -43.8 ± 1.5 | 6.5 ± 1.4 | 7 |
| E1784K | -32.2 ± 1.4a | 7.4 ± 0.5 | 19 |
| K1493A+E1784K | -38.7 ± 0.9a,b | 5.2 ± 0.3 | 9 |
| K1493E+E1784K | -33.6 ± 1.0a | 6.5 ± 0.2 | 27 |
| K1493I+E1784K | -38.4 ± 3.6a | 4.2 ± 0.8 | 5 |
| K1492E+E1784K | -45.7 ± 1.6b | 5.4 ± 0.6 | 9 |
| K1505N | -42.1 ± 1.1a | 5.1 ± 0.3 | 9 |
| K1505E | -41.7 ± 1.7a | 6.1 ± 0.3 | 9 |
Data presented as mean ± SEM.
aP < 0.05 compared to WT.
bP < 0.05 compared to E1784K.