Table 1. Examples of micropeptides codified by human lncRNAs.
| Name (abbreviation) | Number of amino acids | Function | lncRNA | Reference |
|---|---|---|---|---|
| Myoregulin (MRLN) | 46 | Regulates Ca2+ handling by inhibiting the pump activity of SERCA | LINC00948 | Anderson et al., 2015 |
| Small regulatory polypeptide of amino acid response (SPAR) | 90 | Regulates mTORC1 and muscle regeneration | LINC00961 | Matsumoto et al., 2017 |
| Non-annotated P-body dissociating polypeptide (NOBODY) | 68 | Interacts with mRNA-decapping proteins, which are the molecular components of the first enzymatic step in the 5′-to-3′ mRNA decay pathway | LINC01420 | D’Lima et al., 2017 |
| HOXB cluster antisense RNA 3 peptides (HOXB-AS3 peptide) | 53 | Suppresses colon cancer growth; competitively binds to the arginine residue in RGG motif of hnRNP A1 antagonizing its regulation of pyruvate kinase splicing; low levels correlate with poor prognosis | HOXB-AS3 | Huang et al., 2017 |
| Exon 2 of LINC-PINT endogenous circRNA (PINT87aa) | 87 | Suppresses glioblastoma cell proliferation by interaction with polymerase associated factor complex and inhibition of transcriptional elongation of multiple oncogenes | Circular form of LINC-PINT | Zhang et al., 2018 |
SECA, sarcoplasmic reticulum Ca2+-ATPase; hnRNP, heterogeneous nuclear ribonucleoprotein; circRNA, circular RNA.