Table 2: Representative IPA upstream regulator’s z-score and p-value for aging up-regulated genes and CGC Glutamate-up/Candesartan-down regulated genes.

The table includes the z-scores and p-values for GSE11882_Aging_UP and for CGC_Glutamate-UP_Candesartan-Down.

IPA UP- stream regulators	z-score for GSE11882_ Aging_UP	p-value for GSE11882_Aging_ UP	z-score for CGC_ glutamate-UP_ Candesartan- Down	p-value for CGC_glutamate- UP_Candesartan- Down
resveratrol	−1.618	1.49E-06	2.411	2.97E-20
TNF	7.042	3.26E-49	−9.366	7.93E-71
IL6	5.686	2.02E-22	−6.103	3.12E-36
Insulin	1.879	4.78E-07	−1.198	7.21E-08
SIRT1	−2.697	5.43E-06	2.004	1.89E-09
FOXO1	3.896	1.08E-07	−4.695	2.89E-17
FOXO3	2.856	1.65E-08	−4.011	5.92E-19
TP53	4.253	5.97E-24	−4.793	4.07E-26
NFkB (complex)	6.52	2.72E-14	−7.381	8.12E-47
IGF1	4.264	8.11E-10	−5.135	4.00E-28
TGFB1	7.112	7.65E-29	−8.078	1.70E-60
IL1B	6.36	2.58E-31	−8.866	1.32E-53
PI3K (complex)	3.979	1.49E-06	−4.606	8.16E-18
P38 MAPK	3.876	2.19E-12	−5.777	6.24E-31
SMAD3	3.883	6.84E-08	−4.574	1.59E-15
SMAD4	2.318	4.54E-09	−2.852	3.20E-18
Mek	−0.156	8.47E-05	−3.35	6.10E-23
HRAS	1.824	4.56E-24	−2.673	8.01E-33
ERK1/2	3.268	1.89E-08	−4.736	3.74E-23
PTEN	−1.579	6.83E-13	2.116	7.38E-16
TSC2	−4.303	4.49E-13	3.949	3.35E-16
MAPK14	3.33	2.76E-06	−4.292	1.40E-20
JUN	4.161	2.16E-11	−3.877	2.14E-35
FOS	1.686	8.25E-09	−3.339	2.46E-28