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. 2020 Mar 3;11:302. doi: 10.3389/fimmu.2020.00302

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Copyright © 2020 Hun, Wong, Gunawan, Alsharif, Quinn and Chidgey.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phenotypic analysis of TEC subsets in middle-aged female and male mice following degarelix treatment. (A) Total thymocyte cellularity in 8-month-old female and male mice following degarelix treatment. (B) Total TEC cellularity. (C) Proportion of cTEC^lo, cTEC^hi, mTEC^lo, and mTEC^hi subpopulations. (D) Proportion of TEPC, Sca-1^int cTEC^lo, and Sca-1^lo cTEC^lo. (E) Proportion of α6^hi Sca-1^hi mTEC^lo, Sca-1^int mTEC^lo, and Sca-1^lo mTEC^lo. Data presented as mean + SEM (n ≥ 3). * vs. UT. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ordinary one-way ANOVA with Dunnett's multiple comparisons.