Table 2.
Differentially expressed targeted metabolites from the PVC of aged male APOE4/4 vs. APOE3/3 mice.
| Metabolite | Regulation in E4/4 | Fold Change | p-value | FDR | Detection Mode | CAS Number |
|---|---|---|---|---|---|---|
| Fatty Acids | ||||||
| gamma-Linolenic Acid | down | 1.19 | 0.003 | 0.068 | positive | 506-26-3 |
| Palmitic Acid | down | 1.32 | 0.021 | 0.212 | negative | 57-10-3 |
| 10-Hydroxydecanoate | up | 2.22 | 0.015 | 0.195 | positive | 1679-53-4 |
| Docosahexaenoic Acid | down | 2.03 | 0.021 | 0.212 | negative | 6217-54-5 |
| Arachidonic acid | down | 1.45 | 0.021 | 0.212 | negative | 506-32-1 |
| Oligosaccharides | ||||||
| trisaccharide | up | 1.82 | 0.015 | 0.212 | negative | |
| tetrasaccharide | up | 2.70 | 0.021 | 0.212 | negative | |
| Vitamin and Vitamin Derivatives | ||||||
| Dehydroascorbic acid | up | 2.03 | 0.001 | 0.062 | positive | 490-83-5 |
| Phylloquinone | up | 1.90 | 0.001 | 0.062 | positive | 84-80-0 |
| Ascorbic acid | up | 105.84 | 0.005 | 0.192 | negative | 50-81-7 |
| Tocopherol | up | 2.28 | 0.008 | 0.192 | negative | 59-02-9 |
| Energy-Related Metabolites | ||||||
| Acetylcarnitine | up | 1.40 | 0.003 | 0.068 | positive | 3040-38-8 |
| Carnitine | up | 1.31 | 0.011 | 0.154 | positive | 541-15-1 |
| Coenzyme A (CoA) | up | 2.82 | 0.028 | 0.282 | positive | 85-61-0 |
| Pyruvate | up | 1.43 | 0.028 | 0.238 | negative | 127-17-3 |
| Acetoacetic Acid | up | 1.40 | 0.028 | 0.238 | negative | 541-50-4 |
| Cholesterol Metabolites | ||||||
| Taurodeoxycholate | up | 1.94 | 0.003 | 0.068 | positive | 516-50-7 |
| Cholesteryl Acetate | up | 2.24 | 0.008 | 0.192 | negative | 604-35-3 |
| Lanosterol | up | 2.50 | 0.011 | 0.192 | negative | 79-63-0 |
| Amino Acids | ||||||
| Tyrosine | up | 1.25 | 0.037 | 0.270 | negative | 60-18-4 |
| Serine | down | 1.18 | 0.049 | 0.270 | negative | 56-45-1 |
| Glutamate | down | 1.08 | 0.049 | 0.282 | positive | 56-86-0 |
| Cysteine and Methionine Metabolites | ||||||
| Pterin | down | 3.91 | 0.002 | 0.192 | negative | 2236-60-4 |
| Histidine Metabolites | ||||||
| Urocanic acid | down | 1.34 | 0.021 | 0.212 | negative | 104-98-3 |
| Carnosine | up | 1.32 | 0.028 | 0.282 | positive | 305-84-0 |
| Arginine and Proline Metabolites | ||||||
| Phosphocreatine | up | 1.62 | 0.037 | 0.282 | positive | 67-07-2 |
| 4-Guanidinobutyric Acid | down | 1.09 | 0.049 | 0.270 | negative | 463-00-3 |
| Threonine Metabolites | ||||||
| 2-Ketobutyric Acid | up | 1.43 | 0.021 | 0.212 | negative | 600-18-0 |
| Tyrosine Metabolites | ||||||
| Homovanillic Acid | down | 1.30 | 0.049 | 0.270 | negative | 306-08-1 |
| Riboflavin Metabolites | ||||||
| 2, 4-Dihydroxypteridine (Lumazine) | up | 2.07 | 0.008 | 0.154 | positive | 487-21-8 |
| Flavin adenine dinucleotide (FAD) | up | 1.19 | 0.021 | 0.212 | negative | 146-14-5 |
| Lumichrome | down | 1.71 | 0.049 | 0.282 | positive | 1086-80-2 |
| Pyrimidine Metabolites | ||||||
| 2-Aminoisobutyric acid | up | 1.38 | 0.011 | 0.154 | positive | 62-57-7 |
| UMP | up | 1.22 | 0.049 | 0.270 | negative | 58-97-9 |
| CMP | up | 1.29 | 0.049 | 0.282 | positive | 63-37-6 |
| Miscellaneous | ||||||
| Lipoic Acid | up | 3.76 | 0.005 | 0.192 | negative | 1077-28-7 |
| Thiourea | down | 1.45 | 0.008 | 0.192 | negative | 62-56-6 |
| Butyrylcarnitine | up | 1.24 | 0.011 | 0.154 | positive | 25576-40-6 |
| Hydroxybutyric Acid | up | 1.49 | 0.011 | 0.192 | negative | |
| Indoxyl Sulfate | down | 2.12 | 0.021 | 0.212 | negative | 2642-37-7 |
| 3-Hydroxymethylglutaric Acid | up | 1.27 | 0.028 | 0.238 | negative | 503-49-1 |
| 2-Hydroxypyridine | up | 1.45 | 0.037 | 0.282 | positive | 142-08-5 |
| Maleic acid | up | 1.92 | 0.037 | 0.270 | negative | 110-16-7 |
| N-Acetylneuraminic Acid | up | 1.17 | 0.037 | 0.282 | positive | 131-48-6 |
| N-Methylglutamic Acid | down | 1.19 | 0.049 | 0.270 | negative | 35989-16-3 |
| 2-Aminoadipic Acid | down | 1.17 | 0.049 | 0.270 | negative | 542-32-5 |
| Cytidine diphosphate choline (CDPcholine) | down | 1.17 | 0.049 | 0.282 | positive | 987-78-0 |
| Glutathione | up | 1.49 | 0.049 | 0.282 | positive | 70-18-8 |