Table 3.
GO biological processes observed in the PIUMet analysis of differentially expressed untargeted metabolites from the EC of aged male APOE4/4 vs. APOE3/3 mice.
| GO Term | Enrichment | p-value | FDR |
|---|---|---|---|
| carboxylic acid transport | 12.35 | 9.80E-20 | 1.43E-16 |
| carboxylic acid transmembrane transport | 22.34 | 1.36E-16 | 1.04E-13 |
| long-chain fatty acid metabolic process | 18.08 | 2.77E-13 | 1.50E-10 |
| fatty acid metabolic process | 7.8 | 1.45E-11 | 5.40E-09 |
| indolalkylamine metabolic process | 44.68 | 2.48E-09 | 6.68E-07 |
| disaccharide metabolic process | 63.29 | 6.92E-09 | 1.77E-06 |
| IMP metabolic process | 48.69 | 3.47E-08 | 7.43E-06 |
| steroid metabolic process | 6.87 | 1.78E-07 | 3.24E-05 |
| maltose metabolic process | 126.58 | 4.81E-07 | 8.06E-05 |
| kynurenine metabolic process | 50.63 | 7.51E-07 | 1.18E-04 |
| IMP biosynthetic process | 50.63 | 7.51E-07 | 1.19E-04 |
| tryptophan catabolic process | 50.63 | 7.51E-07 | 1.20E-04 |
| 'de novo’ IMP biosynthetic process | 63.29 | 9.46E-06 | 1.13E-03 |
| ketone catabolic process | 3.90E-05 | 3.92E-03 | |
| dopamine metabolic process | 20.25 | 4.12E-05 | 4.06E-03 |
| neurotransmitter catabolic process | 37.97 | 5.54E-05 | 5.25E-03 |
| keratan sulfate catabolic process | 31.65 | 1.00E-04 | 8.37E-03 |
| vitamin metabolic process | 6.38 | 3.60E-04 | 2.35E-02 |