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. 2020 Feb 20;52(2):213–226. doi: 10.1038/s12276-020-0383-3

Table 1.

Cellular reprogramming with small molecules.

Cell type Small molecule Source Species Reference
induced pluripotent stem cells VPA, CHIR99021, 616452, Tranylcypromine Fibroblast Mouse 24
VPA, CHIR99021, 616452, Tranylcypromine, Forskolin, DZNep, EPZ004777, Ch55, AM580

Fibroblast

Neural stem cells

Small intestinal epithelial cells

Mouse 25
Neural stem cells SB-431542, LDN193189, CHIR99021, PD0325901, Pifithrin-α, Forskolin Fibroblast

Mouse

Human

28
A83-01, LDN193189, CHIR99021, Hh-Ag 1.5, Retinoic acid, SMER28, RG108, Parnate, bFGF Fibroblast Mouse 32
Neuronal cells CHIR99021, Dorsomorphin, Forskolin, Go6983, RepSox, SP600125, VPA, Y-27632 Fibroblast Human 36
CHIR99021, DAPT, LDN193189, Purmorphamine, SAG, SB-431542, TTNPB, Tzv, VPA Astrocyte Human 37
Cardiomyocyte CHIR99021, Forskolin, Insulin, LIF, Parnate, PD0325901, RepSox, TTNBP, Vitamin C, VPA Fibroblast Mouse 54
A83-01, AS8351, BIX01294, CHIR99021, JNJ-10198409, OAC2, SC1, SU16F, Y-27632 Fibroblast Human 59
Hepatic progenitor Y-27632, A83-01, CHIR99021, EGF Hepatocyte Mouse 70
HGF, EGF, A83-01, CHIR99021 Hepatocyte Human 76
HGF, EGF, Y-27632, CHIR99021, A83-01, S1P, LPA Hepatocyte Human 79
FGF10, EGF, HGF, human gastrin I, A83-01, Y-27632, Wnt3a Hepatocyte Human 80
Adipocyte Bexarotene, Dexamethasone, Indomethacin, Insulin, Iso-buylmethylxanthine, T3 Skeletal myoblast Mouse 87
β-cell 5-AZA, TSA, Retionic acid, Nicotinamide Liver epithelial stem-like cells Rat 90