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. 2020 Mar 9;10:4373. doi: 10.1038/s41598-020-61378-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Survival outcomes by prognostic scoring. (a) Prognostic scoring without inclusion of first-line treatment data, revealing 3 groups of patients derived from point-wise addition of each adverse factor for OS. (b) Overall survival outcomes by prognostic scoring using Clinico-Genotypic Index (CGI), revealing 4 groups of patients derived from point-wise addition of each independent adverse factor with incorporation of treatment data. Higher number of points on both scoring indices significantly predicted for poorer OS (p < 0.001).