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. 2020 Mar 9;10:4326. doi: 10.1038/s41598-020-61405-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tracheal transplantation and endoscopic analysis. (A) Schematic diagram showing implantation of two-layered tracheal scaffolds in 360° circumferential defects of rabbit trachea. (B) End-to-end implantation of artificial tracheal scaffolds (1.5 cm length) in segmental tracheal defects (yellow arrow, implanted scaffold). (C) Endoscopic images at 4 weeks. Airway patency was well-maintained in all three groups (#, native trachea; *, implanted tracheal graft). (D) Gross findings of implantation site at 4 weeks post-operatively (yellow line, bilateral anastomosis). Macroscopic view of the harvesting of tracheal tissue.