Figure 4.

Linagliptin inhibits tumor growth in HCT116 xenograft nude mice (A): Growth curve of tumor volume in nude mice; (B): Effect of linagliptin and Cyclophosphamide treatment on body weight of nude mice; (C): Change of tumor volume from control, cyclophosphamide, 50 mg/kg and 500 mg/kg linagliptin groups; (D): Linagliptin reduced cell proliferation markers, Ki67, as determined by immunohistochemical staining (40×) and the graphs of H&E staining; (E): The statistical analysis of Ki67 in control and linagliptin treated group showed in (D).