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. 2020 Mar 3;11:187. doi: 10.3389/fphar.2020.00187

Figure 5.

Figure 5

The mechanism of linagliptin inhibits tumor growth in HCT116 (A): GO analysis of down-regulated genes from linagliptin effect gene regulatory network; (B): KEGG analysis of down-regulated genes from linagliptin effect gene regulatory network; (C): GO analysis of up-regulated genes from linagliptin effect gene regulatory network; (D): KEGG analysis of up-regulated genes from linagliptin effect gene regulatory network; (E): the expression levels of p53, Rb, pRbs780, pRbs807/811, Pro-caspase3 and Bcl-2.