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. 2020 Mar 9;10:4307. doi: 10.1038/s41598-020-61275-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Efficacy of SurE_oHSV in combination to PD-1 immune checkpoint blockade in mouse syngeneic established tumour model. (a) Schedule of the treatment. (b) Efficacy of oncolytic virus (SurE_oHSV or R-LM113) and anti PD-1 antibody combination. The four experimental groups were composed as follow: untreated (white squares; N = 8 mice), aPD-1(black circles; N = 8 mice), SurE_oHSV/aPD-1 (up-pointing black triangles; N = 6 mice), R_LM113/aPD-1 (down-pointing black triangles; N = 6 mice). Oncolytic viruses were administered intratumourally (0.5 × 10⁸ PFU/injection) on days 0, 2, 4, 7; anti PD-1 antibody was systemically administered on days 0, 3, 7, 10, 14, 17 by intraperitoneal injections. Cured mice received a second tumour challenge on day 44 (down-pointing white triangles). Fisher test aPD-1 to SurE_oHSV or R-LM113 viruses = 0.05. (c) Kaplan-Meier survival analysis of the experiment outlined in Fig. 5a.