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. 2020 Mar 9;10:4362. doi: 10.1038/s41598-020-60947-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Partial rescue of metabolic indices upon islet-seeded biomaterial implantation into diabetic mice. Islet-seeded biomaterial (n = 6) was intraperitoneal injected into both STZ and NOD mice; control group is empty biomaterial (biomaterial-only; n = 6). Serum samples were collected weekly and assessed for C-peptide, GIP, insulin, leptin, PP, PPY, resistin and amylin hormone secretion in recipient (A) STZ-induced and (B) NOD diabetic mice. Experiments were performed in replicates with 6 mice per group. Data is presented as mean. No values determined after week 6 for STZ-induced and week 5 for NOD diabetic mice due to increasing states of severe morbidity in the control groups.