Fig. 3. DVC astrocytes partly mediate the anorectic effects of leptin in lean but not obese rats.

Changes in cumulative food intake (a, c) and 24-h body weight (b, d) were recorded following 4V icv pretreatment with 50 nmol fluorocitrate and subsequent treatment with 5 μg/mL leptin in rats maintained on either standard chow (n = 10; a, b) or a high-fat diet (n = 7; c, d). Data were analyzed using a 3-way (a, c) or 2-way (b, d) repeated measures ANOVA. Lowercase letters indicate significant differences (p < 0.05) within each time point (a, c) for food intake and at 24 h (b, d) for body weight according to Neuman-Keuls post hoc analyses.