Table 1.
Cytotoxic activity of chromomycins A5 (CA5) and A6 (CA6) against different tumor cells.
| Cell line | Compound IC50 (nM) 72 h (95% confidence interval) | |
|---|---|---|
| CA5 | CA6 | |
| MELANOMA | ||
| 501-mel | 0.8 (0.6–1.0) | 2.0 (1.6–2.4) |
| WM293A | 0.3 (0.2–0.5) | 3.2 (2.4–4.3) |
| MM200 | 0.5 (0.3–1.0) | 4.2 (2.2–8.0) |
| BREAST CARCINOMA | ||
| MCF-7 | 2.1 (1.8–2.5) | 6.5 (5.0–8.4) |
| T47D | 6.5 (5.1–8.9) | 6.8 (2.8–16.3) |
| RHABDOMYOSARCOMA | ||
| RD (Embryonal) | 3.0 (2.8–3.3) | 7.2 (5.6–8.8) |
| RH30 (Alveolar) | 3.5 (3.3–3.6) | 5.5 (3.6–7.3) |
The compounds were incubated during 72 h, and cell viability was measured through the MTT assay. IC50 and the 95% confidence interval were obtained through non-linear regression using GraphPad Prism version 8.0.