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. 2020 Feb 20;52(2):281–292. doi: 10.1038/s12276-020-0389-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a The images show the invasive and noninvasive cells in a zebrafish invasion model. The invasiveness of each cell line in this model is shown in the right panel. b HCT-116 cancer cells were treated with migrastatin and imipramine and then injected into zebrafish larvae. The effect of imipramine in diminishing the cell invasion percentage and the number of invasive cells is similar to that of migrastatin. c Fascin1 mRNA levels in transfected DLD-1 cells and cell invasion associated with transfection (lower panel). d Effect of drugs on the average percentage of zebrafish larvae invasion in fascin1-transfected DLD-1 cells. Data are shown as the mean ± SD, compared with the control, *p = 0.049–0.01; **p = 0.001–0.009; ***p = 0.0001–0.0009; ****p < 0.0001.