Table 1.

List of anticancer drugs according to their effect on intracellular ROS, and types of cancer where are used.

Name	Mechanism to increase ROS	Cancers treated	Ref.
Sulfasalazine	XCT inhibitor	Pancreatic and small-cell lung cancer	69,70
NOV-002	GSSG mimetic	HER2-negative breast cancer	71
Imatinib (PDGFR inhibitor)	Loss of mitochondrial membrane potential	Melanoma	88
Erlotinib (EGFR inhibitor)	Loss of mitochondrial membrane potential	Non-small-cell lung cancer	89
Vemurafenib (BRAF inhibitor)	Depolarization of mitochondrial membrane	Melanoma	90
Rituximab (anti-CD20)	Inhibition of Bcl-2 via mitochondrial ROS	B-cell lymphoma	91
Procarbazine	Oxidized, generates ROS	Hodgkin’s lymphomas, brain cancer	96
Doxorubicin	Fenton’s reaction and electron leakage	Kaposi’s sarc, breast and bladder cancer, ALL	97
Arsenic trioxide	Electron leakage	Myeloma, lung cancer and leukemia	100,101
5-fluorouracil	P53-dependent ROS	Colon and rectal cancer	102,103
2-methoxyestradiol	Loss of mitochondrial membrane potential	Neuroblastoma	104
N-(4-hydroxyphenyl retinamide	Mitochondrial damage	Lung cancer	105
Platinum drugs	ROS-dependent DNA damage	Breast cancer (in ccombination with PARP inhibitors)	106,107
Gamitrinib	Mitochondrial collapse	Prostate cancer	110
ARQ 501 and STA-4783	Leakage of electron transport	Pancreatic adenocarcinoma and solid tumors	111
Bortezomib	ROS due to ER stress	Head and neck squamous cell carcinoma	112
Celecoxib	ROS after ER stress	Prostate cancer	113
Sanguinarine	Electron leakage and induction of NOXs	Glioma	119
Rapamycin	ROS from ER stress	RAS-driven tumors	120