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The roles of platelet-derived exosomes in SCM. Platelet-derived exosomes contain NADPH oxidase subunits similar to phagocytes can produce NO. Also, another component from exosomes, iNOS, can produce NO that is related to myocardial dysfunction in sepsis. NO can cause the up-regulation of GRK2, down-regulation of CXCR2, shedding of L-selectin, decrease in adhesion molecules, and influence of neutrophil chemotaxis.
