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. 2020 Mar 9;10:4363. doi: 10.1038/s41598-020-61381-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Doxycycline causes mitochondrial fragmentation and decreases ΔΨ_m. Fibroblast, A549 and A549 ρ⁰ cultures were treated with vehicle (Veh) or doxycycline (DC) for 5 days, followed by staining with the ΔΨ_m-dependent dye TMRM. (a) Representative fluorescent micrographs of TMRM-stained cells. Scale bar: 10 μm. Inserts show mitochondrial morphology. (b) Mean TMRM fluorescence per mitochondrial mass per cell (n ≥ 36) in arbitrary fluorescent units (AFU). Error bars indicate standard deviations. Asterisks denote statistically significant differences (p < 0.005).