Figure 3.

The Phenotype of Anti-MLSN CAR-T Cells

(A–H) Flow cytometry profile showing the (A and B) transduction efficiencies of CAR-T cells and the (C–H) percentage distribution of CD8⁺, IFNγ⁺CD8⁺, and TNF-α⁺CD8⁺ targeting MSLN CAR-T cells. Representative results from one of six patients are shown. (A and B) The transduction efficiencies of CAR-T-1847 and CAR-T-1848 cells were significantly lower than that of CAR-T-2598 cells (P < 0.001). (C–H) There were no significant differences in the percentages of CD8⁺ CAR-T, IFNγ⁺CD8⁺ CAR-T, and TNFα⁺CD8⁺ CAR-T cells among all three groups (P > 0.05).